Medivizion Transdermal Glucosamine Cream - Work Best To Relieve Joint Pains and Body Pains

How Transdermal Glucosamine Cream (TGC) Works

Transdemal Delivery Technology

Fig 1. Skin Cross Section

Transdermal Drug Delivery is defined as movement of substances (e.g. drugs) across stratum corneum (outer layer of skin) into systemic circulation (blood). In other words, it delivers active ingredients through the skin and directly to the desired area to achieve a better result.

Advantages of Transdemal Delivery

Transdermal offers a number of advantages over the oral delivery:

Reduce drug breakdown by by-passing the digestive system. Therefore, it requires much lower dosage compared to oral route.
Minimize side effects. For example, transdermal estradiol patch doesn't cause liver damage compared to oral estradio pills.

How Transdemal Delivery Works

With the skin regarded as the impeccable external protective barrier of our body, many are sceptical of the true efficacy of transdermal delivery, especially for a hydrophilic nutrient. There are two schools of thought. One uses synthetic liposomes to encapsulate the nutrient and penetrate the skin – which is essentially a lipid bilayer. Another relies on natural oils to carry the nutrient and penetrate the skin to enter the blood stream.

Fig 2. Propriety MediLynk Transdermal Lipovesicular
Technology

Lynk Biotechnologies (who produces our Transdermal Glucosamine Cream products) believes that with the right formulation of natural oils, an effective transdermal delivery of health supplements is possible. To test this hypothesis, a cream formulation comprising: water, glucosamine sulphate (10% w/w), a mixture of natural oils and palmitol was prepared and assayed for bioequivalence in mice.

The results in the lab showed that glucosamine orally fed to the mice at 0.4g/kg body weight gave a plasma level of glucosamine that was hardly detectable even at 6 h post feed. In contrast, topical application of the same dose resulted in an initial surge of glucosamine in the blood within the first 30 min post application. Thereafter, it subsided to a level of approximately 160 µg/ml and sustained at this concentration for beyond 6 h post feed.

Therefore, we conclude that topical application of glucosamine formulated using natural oils results in transdermal delivery of the nutrient through the mouse skin.

Fig 3. Superior of MediLynk transdermal delivery of glucosamine compared
to oral route in mice

Below also shows the transdermal delivery in human trial at Singapore Changi General Hospital

Fig 4. Proven transdermal delivery as demonstrated in human trial at
Singapore Changi General Hospital

About Osteoarthritis

Osteoarthritis (OA) is a universal consequence of aging among vertebrates. It is the most common type of arthritis and its typical targets are the hands, hips, knees, feet, and spine. Sometimes, it attacks the knuckles, wrists, elbows and shoulders. There are 143 joints in the human body and any one of them may be subjected to OA.

OA attacks when there is a degeneration of the cartilage and fluids that protect the bone structure in the body. People with OA usually have joint pain and limited movement. OA affects mainly joints and not internal organs. For example, rheumatoid arthritis—another common form of arthritis--affects other parts of the body besides the joints.

On average, OA sets in at about the age of 50. Before age 45, more men than women have osteoarthritis, whereas after age 45, it is more common in women. By the age of 64, 60% of people suffer from OA in at least one joint. OA used to be put down to ‘wear and tear’ of the joints but while exact cause is still not fully understood. OA hurts people in more than their joints. Their finances and lifestyles also are affected. Financial impact may include the expensive cost of the treatment as well as possibly losing in wages because of disability. Lifestyle effects may include limitation of movement and activities, depression, anxiety, and job limitation. Glucosamine good for sports

OA is more complex than simply passive mechanical degeneration with age. Genes play a major part too. Some kinds of OA are known to be hereditary. It has been known for decades that a susceptibility to OA, especially in the spin, knees, or hip, runs in the families. There is a 2 – 4 folds increased risk among people who have siblings with OA.

The warning signs of OA includes pain, stiffness and swelling around a joint that lasts longer than two weeks. Most often it occurs at the hands, knees, hips or spine.

OA most often affects the small joints of the fingers and the joint at the base of the thumb. Fingers can become enlarged and gnarled. Small, bony knobs (called Heberden's nodes) may also appear on the end joints of the fingers. Similar knobs (called Bouchard's nodes) can appear on the middle joints of the fingers. The sufferer may experience difficulty with pinching movements, such as picking an item up from a table or grasping a pencil or pen.
As the knees are the primary weight-bearing joints of the body, they are among joints which are most commonly affected by OA. The symptoms include stiff, painful, or/and swollen. If not properly treated, OA can lead to disability.
If OA is in the hips, you may experience pain in groin, inner thigh and buttock. It may limit moving, bending, and limping when walking. If not properly treated and the pain is severe, the doctor may recommend hip replacement
OA of the spine can cause stiffness and pain in the neck or in the lower back, as well as weakness or numbness in your arms or legs. Some people feel better when they sleep on a firm mattress or sit using back support pillows. In severe cases, the doctor may suggest surgery to reduce pain and help restore function.

Glucosamine

Glucosamine is an amino sugar produced by our body. It is the building block of glycosaminoglycan - complex carbohydrates found in various types of connective tissue, accounting for 5-20% of the cartilage tissue. As we grow old, however, our body loses the capacity to produce sufficient glucosamine. As a result, many people rely on taking glucosamine orally to supplement their body needs. Studies have shown that glucosamine supplement helps to maintain supple joints, rehabilitate damaged cartilage, and even alleviate pain from arthritis.

Glucosamine in most supplements are derived from the chitin in the exoskeleton of shellfish. Apart from a possible side effect of allergy for people allergic to shell fish, and a remote possibility of complications in diabetic patients, glucosamine is not known to cause any side effects in humans, even at extremely high dosages. (Effects during pregnancy have not been determined to-date.) However, assimilating glucosamine through the oral route subjects the glucosamine to metabolic breakdown even before it reaches the blood. Hence, if transdermal delivery of the nutrient is possible, it definitely surpasses the oral delivery route. This is especially welcome by many since it cuts down the number of pills one has to take with our modern life style.

Advantages of Glucosamine On Osteoarthritis

Glucosamine is a “chondroprotective agent” which relief the systems of OA without any apparent side effects, while at the same time slowing progression of the disease.

Glucosamine is produced naturally by our body. However it is not produced in sufficient quantities when one develops OA. That is the reason why we must rely on an exogenous source to replenish our systems.

Glucosamine is backed by numerous double-blind, placebo-controlled studies and is a very promising treatment for Arthritis. In these studies, Glucosamine stimulated the production of glycosaminoglycans and proteoglycans (the water holding molecules that make up the cartilage).

Glucosamine has been shown to rehabilitate cartilage, reduce the progression of OA, and significantly lessen pain from OA.

“Glucosamine is a topical cream for is specially useful for people already taking lots of oral supplements or medicine. Imaging putting the nutrient right where is needed! No more hit and miss.” Associate professor Lee Chee Wee, National University of Singapore and CEO, Lynk Biotechnologies Pte Ltd.

The advantages of using topical cream as compared to taking oral pills are as follows:

Oral intake of Glucosamine is subjected to metabolic breakdown by our enterophetic system, typically less than 5% effectively reach the blood. Glucosamine topically applied aims to provide a high level of glucosamine directly to the affected joints and cartilage.
Apart from the inconveniences, high oral dosage of glucosamine may cause gastritis, nausea, diarrhea, indigestion and heartburn in some individuals.

Go to ORDER page to purchase Transdermal Glucosamine Cream (TGC).

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