Glucosamine Sulfate in the Treatment of Knee Osteoarthritis Symptoms: A Randomized, Double-Blind, Placebo-Controlled Study Using Acetaminophen as a Side Comparator

Source: Herrero-Beaumont G, Ivorra JAR, Trabado MDC, et al. (Arthritis & Rheumatism. 56:555-567, 2007.)

ABSTRACT

OBJECTIVE

To assess the effects of the prescription formulation of glucosamine sulfate (1,500 mg administered once daily) on the symptoms of knee osteoarthritis (OA) during a 6-month treatment course.

METHODS

Three hundred eighteen patients were enrolled in this randomized, placebo-controlled, double-blind trial in which acetaminophen, the currently preferred medication for symptomatic treatment of OA, was used as a side comparator. Patients were randomly assigned to receive oral glucosamine sulfate 1,500 mg once daily (n = 106), acetaminophen 3 gm/day (n = 108), or placebo (n = 104). The primary efficacy outcome measure was the change in the Lequesne index after 6 months. Secondary parameters included the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) and response according to the Osteoarthritis Research Society International criteria. These outcome measures were assessed using an intent-to-treat analysis.

RESULTS

At baseline, the study patients had moderately severe OA symptoms (mean Lequesne index ~ 11 points). Glucosamine sulfate was more effective than placebo in improving the Lequesne score, with a final decrease of 3.1 points, versus 1.9 with placebo (difference -0.8 [95 % confidence interval -1.9, 0.3]) (p = 0.18). Similar results were observed for the WOMAC. There were more responders to glucosamine sulfate (39.6 %) and acetaminophen (33.3 %) than to placebo (21.2 %) (p = 0.004) and P = 0.047, respectively, versus placebo). Safely was good, and was comparable among groups.

CONCLUSION

The findings of this study indicate that glucosamine sulfate at the oral once-daily dosage of 1,500 mg is more effective than placebo in treating knee OA symptoms. Although acetaminophen also had a higher responder rate compared with placebo, it failed to show significant effects on the algofunctional indexes.
 

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Articles: Topical Cream for Osteoarthritis  |  Glucosamine  |  Transdermal Delivery Technology  |  Glucosamine On Painful Knee Osteoarthritis  |  Long-Term Effects of Glucosamine Sulphate on Osteoarthritis  |  Effect of Glucosamine On Regular Knee Pain  |  Management of Osteoarthritis  |  Glucosamine Effects in Humans  |  Effects of Glucosamine Derivatives on Equine Articular Cartilage Degradation  |  Effect of Glucosamine Supplementation on Fasting and Non-Fasting Plasma Glucose  |  Glucosamine Sulfate Use and Delay of Progression of Knee Osteoarthritis  |  Treatment of Knee Osteoarthritis Symptoms

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