Glucosamine Effects in Humans: A Review of Effects on Glucose Metabolism, Side Effects, Safety Considerations and Efficacy

Source: Anderson JW, Nicolosi RJ and Borzelleca JF. (Food and Chemical Toxicology. 43:187-201, 2005.)

ABSTRACT

Glucosamine is widely used to relieve symptoms from osteoarthritis. Its safety and effects on glucose metabolism are critically evaluated in this review. The LD50 of oral glucosamine in animals is ~1,800 mg/kg with no adverse effects at 2,700 mg/kg for 12 months. Because altered glucose metabolism can be associated with parenteral administration of large doses of glucosamine in animals and with high concentrations in vitro studies, we critically evaluated the clinical importance of these effects. Oral administration of large doses of glucosamine in animals has no documented effects on glucose metabolism. In vitro studies demonstrating effects of glucosamine on glucose metabolism have used concentrations that are 100-200 times higher than tissue levels expected with oral glucosamine administration in humans. We reviewed clinical trial data for 3,063 human subjects. Fasting plasma glucose values decreased slightly for subjects after oral glucosamine for ~66 weeks. There are no adverse effects of oral glucosamine administration on blood, urine or fecal parameters. Side effects were significantly less common glucosamine than placebo or non-steroidal anti-inflammatory drugs (NSAID). In contrast to NSAID, no serious or fatal side effects have been reported for glucosamine. Our critical evaluation indicates that glucosamine is safe under current conditions of use and does not affect glucose metabolism.

Go to ORDER page to purchase Transdermal Glucosamine Cream (TGC).

Home |  Testimonials |  How It Works |  Faq |  Contact Us |  Sitemaps

Articles: Topical Cream for Osteoarthritis  |  Glucosamine  |  Transdermal Delivery Technology  |  Glucosamine On Painful Knee Osteoarthritis  |  Long-Term Effects of Glucosamine Sulphate on Osteoarthritis  |  Effect of Glucosamine On Regular Knee Pain  |  Management of Osteoarthritis  |  Glucosamine Effects in Humans  |  Effects of Glucosamine Derivatives on Equine Articular Cartilage Degradation  |  Effect of Glucosamine Supplementation on Fasting and Non-Fasting Plasma Glucose  |  Glucosamine Sulfate Use and Delay of Progression of Knee Osteoarthritis  |  Treatment of Knee Osteoarthritis Symptoms

Copyright 2009 TransdermalGlucosamine.com. All rights reserved.     Legal Disclaimer  |  Terms & Conditions

Information and statements on this site are provided for informational purposes only. They are not intended to diagnose, treat, cure, or prevent any disease. You should not use the information contained herein for diagnosing or treating any health problem or disease, or prescribing any medication. You should contact your doctor or medical practitioners if you you have a medical problem. You should read carefully all product packaging and labels before using them. We are not responsible or liable for any diagnosis made by a user based on the content of this website